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Smartphone controlled interactive portable device for theranostics in vitro.
- Source :
-
Biosensors & bioelectronics [Biosens Bioelectron] 2019 Dec 15; Vol. 146, pp. 111745. Date of Electronic Publication: 2019 Oct 03. - Publication Year :
- 2019
-
Abstract
- In this work, a smartphone controlled interactive theranostic device has been developed to perform in vitro photodynamic therapy (PDT) and diagnostic assays for treatment assessment on a single platform. Further, silver nanorod (Ag NR) was identified as a photosensitizer and its effect was studied in three different cell lines. PDT was achieved with Ag NRs using low irradiation (1.4 mW/cm <superscript>2</superscript> at 632 nm) from light emitting diodes (LEDs) in the device. Specifically, PDT in conjugation with widely used chemotherapeutic drug doxorubicin (Dox) proved effective in killing of HeLa cancer cells and multicellular tumor spheroids at a minimum dose of Ag (2.5 μg/mL). The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and LDH (lactate dehydrogenase) assays performed with the device indicated the therapeutic success of the delivered PDT. The device is portable and can be adapted for different wavelength irradiations and radiation doses. Additionally, wireless operation using a custom designed smartphone application makes it convenient to use in complex environments without much of human intervention.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Biosensing Techniques instrumentation
Cell Death drug effects
Cell Line, Tumor
Equipment Design
Humans
Neoplasms diagnosis
Photosensitizing Agents chemistry
Silver chemistry
Smartphone
Nanotubes chemistry
Neoplasms drug therapy
Photosensitizing Agents pharmacology
Silver pharmacology
Theranostic Nanomedicine instrumentation
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4235
- Volume :
- 146
- Database :
- MEDLINE
- Journal :
- Biosensors & bioelectronics
- Publication Type :
- Academic Journal
- Accession number :
- 31606688
- Full Text :
- https://doi.org/10.1016/j.bios.2019.111745