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Photoinactivation of microorganisms with sub-micromolar concentrations of imidazolium metallophthalocyanine salts.
- Source :
-
European journal of medicinal chemistry [Eur J Med Chem] 2019 Dec 15; Vol. 184, pp. 111740. Date of Electronic Publication: 2019 Sep 28. - Publication Year :
- 2019
-
Abstract
- The increasingly limited therapeutic options for the treatment of infections caused by multi-resistant Gram-negative bacteria due to the alarming increase in bacteria resistance, renewed interest in photodynamic inactivation (PDI) of bacteria. We address PDI of multi-resistant bacteria with a new family of cationic tetra-imidazolyl phthalocyanines bearing a diversity of cationizing alkylic chain sizes, degrees of cationization and coordinating metals. The antimicrobial activities of the phthalocyanines under white light against Gram-positive and Gram-negative bacteria have remarkable differences in efficacy. We relate their spectroscopic and photophysical properties with the generation of reactive oxygen species (ROS), biological performance and structural features. We show that sub-micromolar concentrations of a Zn(II) tetra-ethyl cationic phthalocyanine reduce colonies of Gram-negative bacteria (E. coli, P. aeruginosa) and C. albicans by 7 log units while leaving mammalian cells unharmed. This is a new lead to address hard-to-treat localized infections.<br /> (Copyright © 2019 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents chemistry
Cell Line
Cell Survival drug effects
Dose-Response Relationship, Drug
Humans
Indoles chemistry
Isoindoles
Microbial Sensitivity Tests
Microscopy, Confocal
Molecular Structure
Optical Imaging
Organometallic Compounds chemical synthesis
Organometallic Compounds chemistry
Photochemical Processes
Photosensitizing Agents chemical synthesis
Photosensitizing Agents chemistry
Salts chemical synthesis
Salts chemistry
Salts pharmacology
Structure-Activity Relationship
Anti-Bacterial Agents pharmacology
Gram-Negative Bacteria drug effects
Gram-Positive Bacteria drug effects
Indoles pharmacology
Organometallic Compounds pharmacology
Photosensitizing Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1768-3254
- Volume :
- 184
- Database :
- MEDLINE
- Journal :
- European journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 31605864
- Full Text :
- https://doi.org/10.1016/j.ejmech.2019.111740