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Peripheral immune biomarkers and neurodegenerative diseases: A prospective cohort study with 20 years of follow-up.
- Source :
-
Annals of neurology [Ann Neurol] 2019 Dec; Vol. 86 (6), pp. 913-926. Date of Electronic Publication: 2019 Oct 18. - Publication Year :
- 2019
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Abstract
- Objective: To assess the associations of several blood immune biomarkers with the future risks of amyotrophic lateral sclerosis and Parkinson disease in a prospective cohort study with 20 years of follow-up.<br />Methods: The Swedish Apolipoprotein-Related Mortality Risk study is a longitudinal cohort study including 812,073 participants with repeated blood biomarker measurements between 1985 and 1996 and a follow-up until 2011. Using a Cox model, we first estimated hazard ratios of amyotrophic lateral sclerosis and Parkinson disease in relation to leukocytes, immunoglobulin G, haptoglobin, and uric acid. We further described the temporal changes of these biomarkers during the 20 years prior to the diagnosis of these diseases.<br />Results: A total of 585 incident cases of amyotrophic lateral sclerosis and 3,769 incident cases of Parkinson disease were identified during the follow-up. Increasing concentrations of leukocytes, haptoglobin, and uric acid were associated with a lower risk of Parkinson disease. No statistically significant association was, however, noted between the studied biomarkers and amyotrophic lateral sclerosis. Parkinson disease patients appeared to have lower levels of leukocytes and haptoglobin between 20 and 10 years before diagnosis and lower levels of uric acid during the 20 years before diagnosis, compared to controls, although statistically significant differences were only noted during parts of the respective time intervals after multivariable adjustment. No clear differences were noted between patients with amyotrophic lateral sclerosis and controls.<br />Interpretation: If verified in studies of independent populations, our findings may suggest a different role of systemic inflammation on the risk of Parkinson disease compared to amyotrophic lateral sclerosis. ANN NEUROL 2019;86:913-926.<br /> (© 2019 American Neurological Association.)
- Subjects :
- Aged
Amyotrophic Lateral Sclerosis epidemiology
Biomarkers blood
Cohort Studies
Female
Follow-Up Studies
Humans
Longitudinal Studies
Male
Middle Aged
Neurodegenerative Diseases blood
Neurodegenerative Diseases epidemiology
Neurodegenerative Diseases immunology
Parkinson Disease epidemiology
Prospective Studies
Sweden epidemiology
Time Factors
Amyotrophic Lateral Sclerosis blood
Amyotrophic Lateral Sclerosis immunology
Immunity, Cellular immunology
Parkinson Disease blood
Parkinson Disease immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1531-8249
- Volume :
- 86
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Annals of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 31604369
- Full Text :
- https://doi.org/10.1002/ana.25614