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Celiac Disease and the Microbiome.
- Source :
-
Nutrients [Nutrients] 2019 Oct 08; Vol. 11 (10). Date of Electronic Publication: 2019 Oct 08. - Publication Year :
- 2019
-
Abstract
- Growing evidence supports the hypothesis that changes in both the composition and function of the intestinal microbiome are associated with a number of chronic inflammatory diseases including celiac disease (CD). One of the major advances in the field of microbiome studies over the last few decades has been the development of culture-independent approaches to identify and quantify the components of the human microbiota. The study of nucleic acids DNA and RNA found in feces or other biological samples bypasses the need for tissue cultures and also allows the characterization of non-cultivable microbes. Current evidence on the composition of the intestinal microbiome and its role as a causative trigger for CD is highly heterogeneous and sometimes contradictory. This review is aimed at summarizing both pre-clinical (basic science data) and clinical (cross-sectional and prospective studies) evidence addressing the relationship between the intestinal microbiome and CD.<br />Competing Interests: All the authors have no conflicts of interest relevant to this article.
- Subjects :
- Adult
Bacteria classification
Bacteria isolation & purification
Bacteroides
Bifidobacterium
Child
Cross-Sectional Studies
Diet
Dysbiosis
Environment
Glutens metabolism
Humans
Immunity
Inflammation
Lactobacillus
Milk, Human
Prospective Studies
Celiac Disease microbiology
Gastrointestinal Microbiome physiology
Subjects
Details
- Language :
- English
- ISSN :
- 2072-6643
- Volume :
- 11
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Nutrients
- Publication Type :
- Academic Journal
- Accession number :
- 31597349
- Full Text :
- https://doi.org/10.3390/nu11102403