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Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner.
- Source :
-
Molecular psychiatry [Mol Psychiatry] 2020 Oct; Vol. 25 (10), pp. 2313-2329. Date of Electronic Publication: 2019 Oct 08. - Publication Year :
- 2020
-
Abstract
- Severe infections during pregnancy are one of the major risk factors for cognitive impairment in the offspring. It has been suggested that maternal inflammation leads to dysfunction of cortical GABAergic interneurons that in turn underlies cognitive impairment of the affected offspring. However, the evidence comes largely from studies of adult or mature brains and how the impairment of inhibitory circuits arises upon maternal inflammation is unknown. Here we show that maternal inflammation affects multiple steps of cortical GABAergic interneuron development, i.e., proliferation of precursor cells, migration and positioning of neuroblasts, as well as neuronal maturation. Importantly, the development of distinct subtypes of cortical GABAergic interneurons was discretely impaired as a result of maternal inflammation. This translated into a reduction in cell numbers, redistribution across cortical regions and layers, and changes in morphology and cellular properties. Furthermore, selective vulnerability of GABAergic interneuron subtypes was associated with the stage of brain development. Thus, we propose that maternally derived insults have developmental stage-dependent effects, which contribute to the complex etiology of cognitive impairment in the affected offspring.
- Subjects :
- Animals
Cell Movement
Cell Proliferation
Cognitive Dysfunction etiology
Cognitive Dysfunction pathology
Female
GABAergic Neurons pathology
Male
Mice
Mice, Inbred C57BL
Pregnancy
Prenatal Exposure Delayed Effects pathology
Cerebral Cortex pathology
Inflammation
Interneurons classification
Interneurons pathology
Mothers
Neurogenesis
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5578
- Volume :
- 25
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Molecular psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 31595033
- Full Text :
- https://doi.org/10.1038/s41380-019-0539-5