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Identification of neurobehavioural symptom groups based on shared brain mechanisms.
- Source :
-
Nature human behaviour [Nat Hum Behav] 2019 Dec; Vol. 3 (12), pp. 1306-1318. Date of Electronic Publication: 2019 Oct 07. - Publication Year :
- 2019
-
Abstract
- Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and executive dysfunction symptoms, respectively, that correlated with distinct sets of brain regions and inter-regional connections, measured by structural and functional neuroimaging modalities. We found that the neural correlates of these symptom groups were present before behavioural symptoms had developed. These neural correlates showed case-control differences in corresponding psychiatric disorders, depression and attention deficit hyperactivity disorder in independent clinical samples. By characterizing behavioural symptom groups based on shared neural mechanisms, our results provide a framework for developing a classification system for psychiatric illness that is based on quantitative neurobehavioural measures.
- Subjects :
- Adolescent
Anisotropy
Anxiety physiopathology
Attention Deficit Disorder with Hyperactivity diagnostic imaging
Attention Deficit Disorder with Hyperactivity physiopathology
Brain physiopathology
Correlation of Data
Depression physiopathology
Depressive Disorder diagnostic imaging
Depressive Disorder physiopathology
Diffusion Tensor Imaging
Female
Functional Neuroimaging
Gray Matter diagnostic imaging
Gray Matter pathology
Humans
Magnetic Resonance Imaging
Male
Neural Pathways diagnostic imaging
Neural Pathways physiopathology
Organ Size
White Matter diagnostic imaging
Young Adult
Anxiety diagnostic imaging
Brain diagnostic imaging
Depression diagnostic imaging
Executive Function
Subjects
Details
- Language :
- English
- ISSN :
- 2397-3374
- Volume :
- 3
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Nature human behaviour
- Publication Type :
- Academic Journal
- Accession number :
- 31591521
- Full Text :
- https://doi.org/10.1038/s41562-019-0738-8