Back to Search
Start Over
Astrocaryum aculeatum fruit improves inflammation and redox balance in phytohemagglutinin-stimulated macrophages.
- Source :
-
Journal of ethnopharmacology [J Ethnopharmacol] 2020 Jan 30; Vol. 247, pp. 112274. Date of Electronic Publication: 2019 Oct 04. - Publication Year :
- 2020
-
Abstract
- Ethnopharmacological Relevance: The fruit of Astrocaryum aculeatum G.Mey. (tucumã) is highly consumed by riverside communities in the Amazonian region. These communities have recently been shown to have increased longevity and reduced prevalence of age-related morbidity. Tucumã, which is locally used in their diet and traditional medicine may contribute to these features.<br />Aim of the Study: To investigate the anti-inflammatory and antioxidant properties of A. aculeatum extract against phytohemagglutinin-induced inflammation in cell cultures.<br />Materials and Methods: Cell viability and cytotoxicity assays, gene expression of interleukins IL-1β, IL-6, IL-10, levels of reactive oxygen species (ROS), nitric oxide (NO) and thiols were employed, as well as the activities of antioxidant enzymes in RAW 264.7 cells stimulated with phytohemagglutinin to mimic inflammation.<br />Results: The extract of A. aculeatum fruit inhibited macrophage proliferation (P < 0.05), arrested the cell cycle in G0/G1 phase (P < 0.001), increased antioxidant defenses (P < 0.01), reduced oxidative stress (P < 0.01), and modulated genes related to the inflammatory response (P < 0.001).<br />Conclusion: Our results demonstrate that A. aculeatum fruit has anti-inflammatory and antioxidant capacities. These beneficial effects of tucumã on cells are also likely to be seen in vivo, thereby suggesting that its extract is a suitable therapeutic adjuvant in the prevention or treatment of inflammatory diseases.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Anti-Inflammatory Agents isolation & purification
Anti-Inflammatory Agents therapeutic use
Antioxidants isolation & purification
Antioxidants therapeutic use
Cell Survival drug effects
Drug Evaluation, Preclinical
Ethnopharmacology
Fruit chemistry
Inflammation immunology
Medicine, Traditional
Mice
Oxidation-Reduction drug effects
Oxidative Stress drug effects
Oxidative Stress immunology
Phytohemagglutinins immunology
Plant Extracts isolation & purification
Plant Extracts therapeutic use
Plants, Edible chemistry
RAW 264.7 Cells
South America
Anti-Inflammatory Agents pharmacology
Antioxidants pharmacology
Arecaceae chemistry
Inflammation drug therapy
Plant Extracts pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7573
- Volume :
- 247
- Database :
- MEDLINE
- Journal :
- Journal of ethnopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 31589969
- Full Text :
- https://doi.org/10.1016/j.jep.2019.112274