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Palladium-catalyzed enantioselective alkenylation of alkenylbenzene derivatives.
- Source :
-
Chemical science [Chem Sci] 2019 Jun 17; Vol. 10 (30), pp. 7246-7250. Date of Electronic Publication: 2019 Jun 17 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- A regioselective and enantioselective palladium-catalyzed relay Heck alkenylation of alkenylbenzene derivatives to construct remote stereocenters is disclosed. Various β-substituted styrenes were readily obtained in moderate yields with good to excellent levels of enantioselectivity. This strategy provides rapid access to enantioenriched δ, ε, ζ, and η-alkenyl aryl compounds from simple starting materials. Mechanistic studies suggest that termination of the relay reaction is controlled by affinity of the arene for the Pd complex during migration.<br /> (This journal is © The Royal Society of Chemistry 2019.)
Details
- Language :
- English
- ISSN :
- 2041-6520
- Volume :
- 10
- Issue :
- 30
- Database :
- MEDLINE
- Journal :
- Chemical science
- Publication Type :
- Academic Journal
- Accession number :
- 31588293
- Full Text :
- https://doi.org/10.1039/c9sc02380a