Parvalbumin Promoter Methylation Altered in Major Depressive Disorder.

Authors :: Thaweethee-Sukjai B
Suttajit S
Thanoi S
Dalton CF
Reynolds GP
Nudmamud-Thanoi S
Source :: International journal of medical sciences [Int J Med Sci] 2019 Aug 14; Vol. 16 (9), pp. 1207-1214. Date of Electronic Publication: 2019 Aug 14 (Print Publication: 2019).
Publication Year :: 2019
Abstract: Aims: To determine the extent of DNA methylation of parvalbumin gene (PVALB) promoter in major depressive disorder (MDD) patients with and without suicide attempt in comparison with healthy controls. Methods: The extracted DNA from dried blood spots of MDD patients (n = 92) including non-suicidal MDD and suicidal-MDD subgroups (n = 45 and n = 47, respectively) and age-matched control subjects (n = 95) was used for DNA methylation analysis at four CpG sites in the promoter sequence of PVALB by pyrosequencing. Results: The PVALB methylation was significantly increased at CpG2 and decreased at CpG4 in the MDD group compared to the control group, while there was no difference between non-suicidal MDD and suicidal-MDD subgroups. A significant inverse correlation of severity of MDD was indicated only for CpG4. Conclusion: This study provides the first evidence of abnormalities of PVALB promoter methylation in MDD and its correlation with MDD severity indicating a role for epigenetics in this psychiatric disorder.<br />Competing Interests: Competing Interests: The authors have declared that no competing interest exists.<br /> (© The author(s).)