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Bioremediation of a Common Product of Food Processing by a Human Gut Bacterium.
- Source :
-
Cell host & microbe [Cell Host Microbe] 2019 Oct 09; Vol. 26 (4), pp. 463-477.e8. Date of Electronic Publication: 2019 Oct 01. - Publication Year :
- 2019
-
Abstract
- Dramatic increases in processed food consumption represent a global health threat. Maillard reaction products (MRPs), which are common in processed foods, form upon heat-induced reaction of amino acids with reducing sugars and include advanced glycation end products with deleterious health effects. To examine how processed foods affect the microbiota, we fed gnotobiotic mice, colonized with 54 phylogenetically diverse human gut bacterial strains, defined sugar-rich diets containing whey as the protein source or a matched amino acid mixture. Whey or ϵ-fructoselysine, an MRP in whey and many processed foods, selectively increases Collinsella intestinalis absolute abundance and induces Collinsella expression of genomic loci directing import and metabolism of ϵ-fructoselysine to innocuous products. This locus is repressed by glucose in C. aerofaciens, whose abundance decreases with whey, but is not repressed in C. intestinalis. Identifying gut organisms responding to and degrading potentially harmful processed food components has implications for food science, microbiome science, and public health.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Subjects :
- Actinobacteria genetics
Animals
Food Quality
Gastrointestinal Microbiome
Germ-Free Life
Humans
Lysine metabolism
Maillard Reaction
Mice
Mice, Inbred C57BL
Whey Proteins metabolism
Actinobacteria metabolism
Fast Foods analysis
Food Safety
Glycation End Products, Advanced metabolism
Lysine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1934-6069
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Cell host & microbe
- Publication Type :
- Academic Journal
- Accession number :
- 31585844
- Full Text :
- https://doi.org/10.1016/j.chom.2019.09.001