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Nonoptimal Vaginal Microbiota After Azithromycin Treatment for Chlamydia trachomatis Infection.
- Source :
-
The Journal of infectious diseases [J Infect Dis] 2020 Feb 03; Vol. 221 (4), pp. 627-635. - Publication Year :
- 2020
-
Abstract
- We characterized the composition and structure of the vaginal microbiota in a cohort of 149 women with genital Chlamydia trachomatis infection at baseline who were followed quarterly for 9 months after antibiotic treatment. At time of diagnosis, the vaginal microbiota was dominated by Lactobacillus iners or a diverse array of bacterial vaginosis-associated bacteria including Gardnerella vaginalis. Interestingly, L. iners-dominated communities were most common after azithromycin treatment (1 g monodose), consistent with the observed relative resistance of L. iners to azithromycin. Lactobacillus iners-dominated communities have been associated with increased risk of C. trachomatis infection, suggesting that the impact of antibiotic treatment on the vaginal microbiota could favor reinfections. These results provide support for the dual need to account for the potential perturbing effect(s) of antibiotic treatment on the vaginal microbiota, and to develop strategies to protect and restore optimal vaginal microbiota.<br /> (© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.)
- Subjects :
- Adolescent
Adult
Anti-Bacterial Agents administration & dosage
Anti-Bacterial Agents adverse effects
Anti-Bacterial Agents pharmacology
Azithromycin administration & dosage
Azithromycin adverse effects
Azithromycin pharmacology
Chlamydia Infections microbiology
Cross-Sectional Studies
Female
Follow-Up Studies
Gardnerella vaginalis drug effects
Gardnerella vaginalis genetics
Humans
Lactobacillus drug effects
Lactobacillus genetics
Microbiota genetics
Prospective Studies
RNA, Ribosomal, 16S
Treatment Outcome
Vaginosis, Bacterial microbiology
Young Adult
Anti-Bacterial Agents therapeutic use
Azithromycin therapeutic use
Chlamydia Infections drug therapy
Chlamydia trachomatis genetics
Microbiota drug effects
Vagina microbiology
Vaginosis, Bacterial drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6613
- Volume :
- 221
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 31573603
- Full Text :
- https://doi.org/10.1093/infdis/jiz499