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The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia.
- Source :
-
Cold Spring Harbor perspectives in medicine [Cold Spring Harb Perspect Med] 2020 Mar 02; Vol. 10 (3). Date of Electronic Publication: 2020 Mar 02. - Publication Year :
- 2020
-
Abstract
- T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy derived from early T-cell progenitors. The recognition of clinical, genetic, transcriptional, and biological heterogeneity in this disease has already translated into new prognostic biomarkers, improved leukemia animal models, and emerging targeted therapies. This work reviews our current understanding of the molecular mechanisms of T-ALL.<br /> (Copyright © 2020 Cold Spring Harbor Laboratory Press; all rights reserved.)
- Subjects :
- Animals
Antineoplastic Agents therapeutic use
Disease Models, Animal
Gene Expression Regulation, Leukemic
Humans
Mutation
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma drug therapy
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma metabolism
Receptor, Notch1 metabolism
Biomarkers, Tumor genetics
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma genetics
Receptor, Notch1 antagonists & inhibitors
Receptor, Notch1 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2157-1422
- Volume :
- 10
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cold Spring Harbor perspectives in medicine
- Publication Type :
- Academic Journal
- Accession number :
- 31570389
- Full Text :
- https://doi.org/10.1101/cshperspect.a035246