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Predicting stress resilience and vulnerability: brain-derived neurotrophic factor and rapid eye movement sleep as potential biomarkers of individual stress responses.
- Source :
-
Sleep [Sleep] 2020 Jan 13; Vol. 43 (1). - Publication Year :
- 2020
-
Abstract
- Study Objectives: To examine the rapid eye movement sleep (REM) response to mild stress as a predictor of the REM response to intense stress and brain-derived neurotrophic factor (BDNF) as a potential biomarker of stress resilience and vulnerability.<br />Methods: Outbred Wistar rats were surgically implanted with electrodes for recording electroencephalography (EEG) and electromyogram (EMG) and intraperitoneal Data loggers to record body temperature. Blood was also obtained to measure circulating BDNF. After recovery, rats were exposed to mild stress (novel chamber, NC) and later intense stress (shock training, ST), followed by sleep recording. Subsequently, rats were separated into resilient (Res; n=27) or vulnerable (Vul; n = 15) based on whether or not there was a 50% or greater decrease in REM after ST compared to baseline. We then compared sleep, freezing, and the stress response (stress-induced hyperthermia, SIH) across groups to determine the effects of mild and intense stress to determine if BDNF was predictive of the REM response.<br />Results: REM totals in the first 4 hours of sleep after exposure to NC predicted REM responses following ST with resilient animals having higher REM and vulnerable animals having lower REM. Resilient rats had significantly higher baseline peripheral BDNF compared to vulnerable rats.<br />Conclusions: These results show that outbred rats display significant differences in post-stress sleep and peripheral BDNF identifying these factors as potential markers of resilience and vulnerability prior to traumatic stress.<br /> (© Sleep Research Society 2019. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.)
- Subjects :
- Animals
Biomarkers
Body Temperature
Disease Models, Animal
Electroencephalography
Electromyography
Fear physiology
Male
Rats
Rats, Wistar
Stress Disorders, Post-Traumatic psychology
Stress, Psychological psychology
Adaptation, Psychological physiology
Brain-Derived Neurotrophic Factor blood
Resilience, Psychological
Sleep, REM physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1550-9109
- Volume :
- 43
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Sleep
- Publication Type :
- Academic Journal
- Accession number :
- 31556950
- Full Text :
- https://doi.org/10.1093/sleep/zsz199