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Hyperpolarised 13 C MRI: a new horizon for non-invasive diagnosis of aggressive breast cancer.

Authors :
Abeyakoon O
Latifoltojar A
Gong F
Papoutsaki MV
Chowdhury R
Glaser M
Jeraj H
Awais R
Holt C
Twyman F
Arstad E
Gadian DG
Atkinson D
Comment A
O'Callaghan J
Smith L
Beeston T
Clemente J
Patani N
Stein R
Yuneva M
Szabadkai G
Halligan S
Punwani S
Source :
BJR case reports [BJR Case Rep] 2019 May 15; Vol. 5 (3), pp. 20190026. Date of Electronic Publication: 2019 May 15 (Print Publication: 2019).
Publication Year :
2019

Abstract

Hyperpolarised <superscript>13</superscript> C MRI (HP-MRI) is a novel imaging technique that allows real-time analysis of metabolic pathways in vivo . <superscript>1</superscript> The technology to conduct HP-MRI in humans has recently become available and is starting to be clinically applied. As knowledge of molecular biology advances, it is increasingly apparent that cancer cell metabolism is related to disease outcomes, with lactate attracting specific attention. <superscript>2</superscript> Recent reviews of breast cancer screening programs have raised concerns and increased public awareness of over treatment. The scientific community needs to shift focus from improving cancer detection alone to pursuing novel methods of distinguishing aggressive breast cancers from those which will remain indolent. HP-MRI offers the opportunity to identify aggressive tumour phenotypes and help monitor/predict therapeutic response. Here we report one of the first cases of breast cancer imaged using HP-MRI alongside correlative conventional imaging, including breast MRI.

Details

Language :
English
ISSN :
2055-7159
Volume :
5
Issue :
3
Database :
MEDLINE
Journal :
BJR case reports
Publication Type :
Academic Journal
Accession number :
31555479
Full Text :
https://doi.org/10.1259/bjrcr.20190026