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A new steroid glycoside from Begonia sp. : cytotoxic activity and docking studies.
- Source :
-
Natural product research [Nat Prod Res] 2021 Jul; Vol. 35 (13), pp. 2224-2231. Date of Electronic Publication: 2019 Sep 26. - Publication Year :
- 2021
-
Abstract
- Chemical investigation on the ethyl acetate extract of the aerial parts of Begonia sp. afforded a new steroid glycoside, 9(11)α,16(17)α-dioxirane-20,25-dihydroxy-β-sitosterol-3- O -β-glucopyranoside ( 1 ) along with a known steroidal glycoside, β-sitosterol-3- O -β-D-glucopyranoside ( 2 ). The Chemical structures were elucidated by 1D and 2D NMR and mass spectroscopic analysis. Cytotoxicity against four different cancer cell lines (HeLa, T47D, WiDr and Vero) was assessed. Compound 1 was more potent and selective against breast cancer cell line (T47D) than other cell lines with an IC <subscript>50</subscript> value of 0.16 µg/mL. Further docking study of 1 exhibited the preference of molecule to bind in the epidermal growth factor receptor tyrosine kinase (EGFR-TK) binding pockets with docking scores of -97.8800 (PLANTS) and -3.56 kcal/mol (AutoDock 4.2.6).
- Subjects :
- Cell Death drug effects
Cell Line, Tumor
Glycosides chemistry
Glycosides pharmacology
Humans
Proton Magnetic Resonance Spectroscopy
Steroids chemistry
Steroids pharmacology
Begoniaceae chemistry
Glycosides isolation & purification
Molecular Docking Simulation
Steroids isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6427
- Volume :
- 35
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Natural product research
- Publication Type :
- Academic Journal
- Accession number :
- 31554438
- Full Text :
- https://doi.org/10.1080/14786419.2019.1669026