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IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update.
- Source :
-
Twin research and human genetics : the official journal of the International Society for Twin Studies [Twin Res Hum Genet] 2019 Dec; Vol. 22 (6), pp. 809-816. Date of Electronic Publication: 2019 Sep 23. - Publication Year :
- 2019
-
Abstract
- The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 18 twin studies from 5 different countries (Sweden, Denmark, Finland, United States, and Australia) established to explore the nature of gene-environment (GE) interplay in functioning across the adult lifespan. Fifteen of the studies are longitudinal, with follow-up as long as 59 years after baseline. The combined data from over 76,000 participants aged 14-103 at intake (including over 10,000 monozygotic and over 17,000 dizygotic twin pairs) support two primary research emphases: (1) investigation of models of GE interplay of early life adversity, and social factors at micro and macro environmental levels and with diverse outcomes, including mortality, physical functioning and psychological functioning; and (2) improved understanding of risk and protective factors for dementia by incorporating unmeasured and measured genetic factors with a wide range of exposures measured in young adulthood, midlife and later life.
Details
- Language :
- English
- ISSN :
- 1832-4274
- Volume :
- 22
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Twin research and human genetics : the official journal of the International Society for Twin Studies
- Publication Type :
- Academic Journal
- Accession number :
- 31544729
- Full Text :
- https://doi.org/10.1017/thg.2019.76