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Chitooligosaccharide inhibits RANKL-induced osteoclastogenesis and ligation-induced periodontitis by suppressing MAPK/ c-fos/NFATC1 signaling.
- Source :
-
Journal of cellular physiology [J Cell Physiol] 2020 Mar; Vol. 235 (3), pp. 3022-3032. Date of Electronic Publication: 2019 Sep 20. - Publication Year :
- 2020
-
Abstract
- Considering the high rate of osteoclast-related diseases worldwide, research targeting osteoclast formation/function is crucial. In vitro, we demonstrated that chitooligosaccharide (CS) dramatically inhibited osteoclastogenesis as well as osteoclast function dose-dependently. CS suppressed osteoclast-specific genes expression during osteoclastogenesis. Furthermore, we found that CS attenuated receptor activator of nuclear factor kappa B ligand (RANKL)-mediated mitogen-activated protein kinase (MAPK) pathway involving p38, erk1/2, and jnk, leading to the reduced expression of c-fos and nuclear factor of activated T cells c1 (NFATc1) during osteoclast differentiation. In vivo, we found CS protected rats from periodontitis-induced alveolar bone loss by micro-computerized tomography and histological analysis. Overall, CS inhibited RANKL-induced osteoclastogenesis and ligature-induced rat periodontitis model, probably by suppressing the MAPK/c-fos/NFATc1 signaling pathway. Therefore, CS may be a safe and promising treatment for osteoclast-related diseases.<br /> (© 2019 Wiley Periodicals, Inc.)
- Subjects :
- Animals
Bone Marrow Cells drug effects
Bone Marrow Cells metabolism
Cell Differentiation drug effects
Chitin pharmacology
Chitosan
Mitogen-Activated Protein Kinases metabolism
Mitogens pharmacology
NFATC Transcription Factors metabolism
Oligosaccharides
Osteoclasts metabolism
Proto-Oncogene Proteins c-fos metabolism
RANK Ligand metabolism
Rats
Chitin analogs & derivatives
Osteogenesis drug effects
RANK Ligand drug effects
Signal Transduction drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4652
- Volume :
- 235
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of cellular physiology
- Publication Type :
- Academic Journal
- Accession number :
- 31541460
- Full Text :
- https://doi.org/10.1002/jcp.29207