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Current concepts on cleft lip and palate etiology.
- Source :
-
Journal of biological regulators and homeostatic agents [J Biol Regul Homeost Agents] 2019 May-Jun; Vol. 33 (3 Suppl. 1), pp. 145-151. DENTAL SUPPLEMENT. - Publication Year :
- 2019
-
Abstract
- Nonsyndromic cleft lip with or without cleft palate is the most common craniofacial anomaly affecting around 1 in 700 live births worldwide. Clefts of the human face can be classified anatomically as cleft palate only (CPO), cleft lip only (CLO), cleft lip and palate (CLP) or a combined group of cleft lip with or without cleft palate (CL/P), based on different in embryologic development. These malformations have some genetic origin, in fact several association studies have been performed to obtain important information about the candidate genes; but more important are gene-environment interactions that play an increasing role in its etiology. Epidemiological studies have shown how environmental factors (alcohol, smoking, drugs), as well as possible gene-environment interactions, play an important role in the onset of the malformation. On the contrary, folic acid intake seems to have a protective effect. In this review, we analyze the role of environmental factors related to onset of cleft.<br /> (Copyright 2019 Biolife Sas. www.biolifesas.org.)
Details
- Language :
- English
- ISSN :
- 0393-974X
- Volume :
- 33
- Issue :
- 3 Suppl. 1
- Database :
- MEDLINE
- Journal :
- Journal of biological regulators and homeostatic agents
- Publication Type :
- Academic Journal
- Accession number :
- 31538461