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Intrinsic mitotic activity supports the human salivary gland acinar cell population.
- Source :
-
FEBS letters [FEBS Lett] 2020 Jan; Vol. 594 (2), pp. 376-382. Date of Electronic Publication: 2019 Oct 02. - Publication Year :
- 2020
-
Abstract
- To develop treatments for salivary gland dysfunction, it is important to understand how human salivary glands are maintained under normal homeostasis. Previous data from our lab demonstrated that murine salivary acinar cells maintain the acinar cell population through self-duplication under conditions of homeostasis, as well as after injury. Early studies suggested that human acinar cells are mitotically active, but the identity of the resultant daughter cells was not clear. Using markers of cell cycle activity and mitosis, as well as an ex vivo 5-Ethynyl-2´-deoxyuridine assay, we show that human salivary gland acinar cells divide to generate daughter acinar cells. As in mouse, our data indicate that human salivary gland homeostasis is supported by the intrinsic mitotic capacity of acinar cells.<br /> (© 2019 Federation of European Biochemical Societies.)
- Subjects :
- Animals
Cell Cycle genetics
Cell Differentiation drug effects
Deoxyuridine analogs & derivatives
Deoxyuridine pharmacology
Epithelial Cells cytology
Epithelial Cells drug effects
Humans
Mice
Salivary Glands cytology
Acinar Cells cytology
Cell Differentiation genetics
Mitosis genetics
Salivary Glands growth & development
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3468
- Volume :
- 594
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- FEBS letters
- Publication Type :
- Academic Journal
- Accession number :
- 31538335
- Full Text :
- https://doi.org/10.1002/1873-3468.13611