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Serum Annexin V and Anti-Annexin V levels and their relationship with metabolic parameters in patients with type 2 diabetes.
- Source :
-
Revista da Associacao Medica Brasileira (1992) [Rev Assoc Med Bras (1992)] 2019 Sep 12; Vol. 65 (8), pp. 1042-1047. Date of Electronic Publication: 2019 Sep 12. - Publication Year :
- 2019
-
Abstract
- Background: We investigated the serum annexin V and anti-annexin V levels and their relationship with metabolic parameters in patients recently diagnosed type 2 diabetic.<br />Methods: A total of 143 patients recently diagnosed type 2 diabetes and 133 control subjects were included in the study. Body mass index (BMI), hs-CRP, HOMA-IR, carotid intima-media thickness, and serum levels of annexin V and anti-annexin V were investigated.<br />Results: HOMA-IR, serum hs-CRP, and carotid intima-media thickness were found to be statistically significant. The Pearson correlation analysis revealed a statistically significant positive relationship between the carotid intima-media thickness and the annexin V level (r=0.29, p=0.006*). A statistically significant positive relationship was also detected between the Annexin V level and level of serum hs-CRP (r=0.29 p=0.006*).<br />Conclusion: A positive relationship was observed between the carotid intima-media thickness and annexin V at the end of our investigation. In this regard, we also believe that serum levels of annexin V may be increased for cardiovascular protection in the elevation of carotid intima-media thickness.
- Subjects :
- Adult
Aged
Annexin A5 immunology
Annexin A5 metabolism
Body Mass Index
Carotid Intima-Media Thickness
Case-Control Studies
Cross-Sectional Studies
Diabetes Mellitus, Type 2 metabolism
Female
Homeostasis
Humans
Male
Middle Aged
Annexin A5 blood
Autoantibodies blood
Diabetes Mellitus, Type 2 blood
Subjects
Details
- Language :
- English
- ISSN :
- 1806-9282
- Volume :
- 65
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Revista da Associacao Medica Brasileira (1992)
- Publication Type :
- Academic Journal
- Accession number :
- 31531599
- Full Text :
- https://doi.org/10.1590/1806-9282.65.8.1042