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The effects of developmental alcohol exposure on the neurobiology of spatial processing.
- Source :
-
Neuroscience and biobehavioral reviews [Neurosci Biobehav Rev] 2019 Dec; Vol. 107, pp. 775-794. Date of Electronic Publication: 2019 Sep 14. - Publication Year :
- 2019
-
Abstract
- The consumption of alcohol during gestation is detrimental to the developing central nervous system. One functional outcome of this exposure is impaired spatial processing, defined as sensing and integrating information pertaining to spatial navigation and spatial memory. The hippocampus, entorhinal cortex, and anterior thalamus are brain regions implicated in spatial processing and are highly susceptible to the effects of developmental alcohol exposure. Some of the observed effects of alcohol on spatial processing may be attributed to changes at the synaptic to circuit level. In this review, we first describe the impact of developmental alcohol exposure on spatial behavior followed by a summary of the development of brain areas involved in spatial processing. We then provide an examination of the consequences of prenatal and early postnatal alcohol exposure in rodents on hippocampal, anterior thalamus, and entorhinal cortex-dependent spatial processing from the cellular to behavioral level. We conclude by highlighting several unanswered questions which may provide a framework for future investigation.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Entorhinal Cortex drug effects
Entorhinal Cortex physiopathology
Female
Hippocampus drug effects
Hippocampus physiopathology
Humans
Mice
Pregnancy
Prenatal Exposure Delayed Effects psychology
Thalamus drug effects
Thalamus physiopathology
Ethanol adverse effects
Prenatal Exposure Delayed Effects physiopathology
Spatial Navigation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-7528
- Volume :
- 107
- Database :
- MEDLINE
- Journal :
- Neuroscience and biobehavioral reviews
- Publication Type :
- Academic Journal
- Accession number :
- 31526818
- Full Text :
- https://doi.org/10.1016/j.neubiorev.2019.09.018