Utilization of CAR T Cell Therapy in Pediatric Patients.

Authors :: Szenes V
Curran KJ
Source :: Seminars in oncology nursing [Semin Oncol Nurs] 2019 Oct; Vol. 35 (5), pp. 150929. Date of Electronic Publication: 2019 Sep 13.
Publication Year :: 2019
Abstract: Objective: To provide an overview of chimeric antigen receptor (CAR) T cell therapy for pediatric patients with relapsed or refractory malignancy and the associated toxicities.<br />Data Sources: Research articles, reviews, clinical trial information.<br />Conclusion: The key to the successful application of CAR T cell immunotherapy is (1) identifying patients with malignancies that are eligible for immunotherapy, (2) coordinating T-cell collection, (3) safe infusion of CAR T cells, and (4) managing/preventing toxicities following infusion.<br />Implications for Nursing Practice: As the use of targeted therapy with tumor-specific T cells becomes more prevalent, it is essential that the nursing staff stay abreast of these current therapies.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)