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Rhinovirus Type in Severe Bronchiolitis and the Development of Asthma.
- Source :
-
The journal of allergy and clinical immunology. In practice [J Allergy Clin Immunol Pract] 2020 Feb; Vol. 8 (2), pp. 588-595.e4. Date of Electronic Publication: 2019 Sep 11. - Publication Year :
- 2020
-
Abstract
- Background: Respiratory syncytial virus (RSV)- and rhinovirus (RV)-induced bronchiolitis are associated with an increased risk of asthma, but more detailed information is needed on virus types.<br />Objective: To study whether RSV or RV types are differentially associated with the future use of asthma control medication.<br />Methods: Over 2 consecutive winter seasons (2008-2010), we enrolled 408 children hospitalized for bronchiolitis at age less than 24 months into a prospective, 3-center, 4-year follow-up study in Finland. Virus detection was performed by real-time reverse transcription PCR from nasal wash samples. Four years later, we examined current use of asthma control medication.<br />Results: A total of 349 (86%) children completed the 4-year follow-up. At study entry, the median age was 7.5 months, and 42% had RSV, 29% RV, 2% both RSV and RV, and 27% non-RSV/-RV etiology. The children with RV-A (adjusted hazard ratio, 2.3; P = .01), RV-C (adjusted hazard ratio, 3.5; P < .001), and non-RSV/-RV (adjusted hazard ratio, 2.0; P = .004) bronchiolitis started the asthma control medication earlier than did children with RSV bronchiolitis. Four years later, 27% of patients used asthma control medication; both RV-A (adjusted odds ratio, 3.0; P = .03) and RV-C (adjusted odds ratio, 3.7; P < .001) etiology were associated with the current use of asthma medication. The highest risk was found among patients with RV-C, atopic dermatitis, and fever (adjusted odds ratio, 5.0; P = .03).<br />Conclusions: Severe bronchiolitis caused by RV-A and RV-C was associated with earlier initiation and prolonged use of asthma control medication. The risk was especially high when bronchiolitis was associated with RV-C, atopic dermatitis, and fever.<br /> (Copyright © 2019 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Child
Child, Preschool
Finland epidemiology
Follow-Up Studies
Humans
Infant
Male
Prospective Studies
Respiratory Sounds
Asthma drug therapy
Asthma epidemiology
Asthma virology
Bronchiolitis drug therapy
Bronchiolitis epidemiology
Influenza A Virus, H1N1 Subtype
Picornaviridae Infections complications
Rhinovirus classification
Rhinovirus pathogenicity
Subjects
Details
- Language :
- English
- ISSN :
- 2213-2201
- Volume :
- 8
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The journal of allergy and clinical immunology. In practice
- Publication Type :
- Academic Journal
- Accession number :
- 31520837
- Full Text :
- https://doi.org/10.1016/j.jaip.2019.08.043