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Trichotillomania comorbidity in a sample enriched for familial obsessive-compulsive disorder.
- Source :
-
Comprehensive psychiatry [Compr Psychiatry] 2019 Oct; Vol. 94, pp. 152123. Date of Electronic Publication: 2019 Aug 31. - Publication Year :
- 2019
-
Abstract
- Background: This study addresses the strength of associations between trichotillomania (TTM) and other DSM-IV Axis I conditions in a large sample (n = 2606) enriched for familial obsessive-compulsive disorder (OCD), to inform TTM classification.<br />Methods: We identified participants with TTM in the Johns Hopkins OCD Family Study (153 families) and the OCD Collaborative Genetics Study, a six-site genetic linkage study of OCD (487 families). We used logistic regression (with generalized estimating equations) to assess the strength of associations between TTM and other DSM-IV disorders.<br />Results: TTM had excess comorbidity with a number of conditions from different DSM-IV chapters, including tic disorders, alcohol dependence, mood disorders, anxiety disorders, impulse-control disorders, and bulimia nervosa. However, association strengths (odds ratios) were highest for kleptomania (6.6), pyromania (5.8), OCD (5.6), skin picking disorder (4.4), bulimia nervosa (3.5), and pathological nail biting (3.4).<br />Conclusions: TTM is comorbid with a number of psychiatric conditions besides OCD, and it is strongly associated with other conditions involving impaired impulse control. Though DSM-5 includes TTM as an OCD-related disorder, its comorbidity pattern also emphasizes the impulsive, appetitive aspects of this condition that may be relevant to classification.<br /> (Copyright © 2019. Published by Elsevier Inc.)
- Subjects :
- Adult
Comorbidity
Diagnostic and Statistical Manual of Mental Disorders
Disruptive, Impulse Control, and Conduct Disorders genetics
Female
Genetic Linkage
Humans
Male
Middle Aged
Obsessive-Compulsive Disorder genetics
Trichotillomania genetics
Young Adult
Disruptive, Impulse Control, and Conduct Disorders epidemiology
Obsessive-Compulsive Disorder epidemiology
Trichotillomania epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-8384
- Volume :
- 94
- Database :
- MEDLINE
- Journal :
- Comprehensive psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 31518848
- Full Text :
- https://doi.org/10.1016/j.comppsych.2019.152123