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Periodontal regeneration using bone morphogenetic protein 2 incorporated biomimetic calcium phosphate in conjunction with barrier membrane: A pre-clinical study in dogs.
- Source :
-
Journal of clinical periodontology [J Clin Periodontol] 2019 Dec; Vol. 46 (12), pp. 1254-1263. Date of Electronic Publication: 2019 Oct 07. - Publication Year :
- 2019
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Abstract
- Aim: To evaluate the effect of bone morphogenetic protein 2 (BMP-2) incorporated biomimetic calcium phosphate (BMP-2/BioCaP) in conjunction with barrier membrane on periodontal regeneration in chronic periodontitis experimental model.<br />Material and Methods: Chronic periodontitis experimental model with critical-sized supra-alveolar defects was created in 15 dogs' mandibles. After the initial periodontal therapy, the defects were randomly assigned to the following groups: (a) control; (b) barrier membrane; (c) deproteinized bovine bone mineral + barrier membrane; (d) BioCaP + barrier membrane and (e) BMP-2/BioCaP + barrier membrane (6 quadrants with 18 teeth per group). Eight weeks later, clinical examinations, micro-CT, and histomorphometric analyses were performed.<br />Results: Clinical examinations, including plaque index, bleeding index, and probing depth, were similar for all groups. In contrast, the clinical attachment loss was significantly lower in defects grafted with BMP-2/BioCaP and barrier membrane. The micro-CT results showed that the height of mineralized tissue in defects grafted with BMP-2/BioCaP and barrier membrane was significantly higher. For histometric analysis, the defects grafted with BMP-2/BioCaP and barrier membrane exhibited significantly more connective tissue height, new cementum height, new bone height and area, as well as less down-growth of junctional epithelium.<br />Conclusion: BMP-2/BioCaP could be a promising bone substitute for periodontal regeneration.<br /> (© 2019 The Authors. Journal of Clinical Periodontology published by John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1600-051X
- Volume :
- 46
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of clinical periodontology
- Publication Type :
- Academic Journal
- Accession number :
- 31518453
- Full Text :
- https://doi.org/10.1111/jcpe.13195