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A case with neurological abnormalities caused by Rickettsia raoultii in northwestern China.
- Source :
-
BMC infectious diseases [BMC Infect Dis] 2019 Sep 11; Vol. 19 (1), pp. 796. Date of Electronic Publication: 2019 Sep 11. - Publication Year :
- 2019
-
Abstract
- Background: The number of new rickettsial species are rapidly increasing, and increasing numbers of Rickettsia raoultii (R. raoultii) infection cases have been detected in humans. However, neurological abnormalities caused by R. raoultii are rarely reported, especially in northwestern China.<br />Case Presentation: A 36-year-old Kazakh shepherd with an attached tick on part temporalis, presented with right eyelid droop, lethargy, fever, headache, fever (38.0-41.0 °C) and erythematous rash. The examination of cerebrospinal fluid (CSF) showed cerebrospinal pressure of 200 mm H <subscript>2</subscript> O, leukocyte count of 300.0 × 10 <superscript>6</superscript> /L, adenosine deaminase of 2.15 U/L, and total protein concentration of 0.93 g/L. The diagnosis of R. raoultii infection was confirmed by six genetic markers, and semi-quantified by enzyme-linked immunosorbent assay for rickettsial antigen. The patient gradually recovered after treatment with doxycycline and ceftriaxone. R. raoultii DNA was found both in a tick detached from this patient and in 0.18% (2/1107) of blood samples collected from local shepherds.<br />Conclusions: This is the first reported case with neurological abnormalities caused by R. raoultii in northwestern China. It is vital to detect rickettsial agents both in blood and CSF for tick bite patients with neurological abnormalities. Public health workers and physicians should pay attention to neurological abnormalities caused by Rickettsia.
- Subjects :
- Adenosine Deaminase cerebrospinal fluid
Adult
Animals
Antigens, Bacterial analysis
Antigens, Bacterial immunology
Ceftriaxone therapeutic use
China
DNA, Bacterial blood
Doxycycline therapeutic use
Humans
Leukocyte Count
Male
Nervous System Diseases etiology
Phylogeny
RNA, Ribosomal, 16S metabolism
Rickettsia classification
Rickettsia genetics
Rickettsia Infections complications
Rickettsia Infections drug therapy
Tick Bites complications
Ticks genetics
Nervous System Diseases diagnosis
Rickettsia metabolism
Rickettsia Infections diagnosis
Tick Bites diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2334
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 31510926
- Full Text :
- https://doi.org/10.1186/s12879-019-4414-4