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Oligoclonal bands staining for IgG, IgA, IgM, and kappa and lambda light chains in cerebrospinal fluid of patients with multiple sclerosis.
- Source :
-
The Japanese journal of psychiatry and neurology [Jpn J Psychiatry Neurol] 1988 Dec; Vol. 42 (4), pp. 805-9. - Publication Year :
- 1988
-
Abstract
- We investigated the oligoclonal bands (OB) in CSF of patients with multiple sclerosis (MS), Guillain-Barré syndrome (GBS) and aseptic meningitis (AS) using polyacryamide or agarose isoelectric focusing following electroblotting and immunostaining for IgG, IgA, IgM and light chains. OB staining for IgG was detected in 80% of patients with MS, 25% with GBS and 13% with AS. OB staining for IgA and IgM was not detected in any disease. In MS, OB were stained only for the kappa or lambda light chains, which was compatible with OB staining for IgG. These results suggest that in MS, OB are monoclonal because they can be stained for gamma heavy chains and for only one light chains.
- Subjects :
- Humans
Immunoglobulin A cerebrospinal fluid
Immunoglobulin G cerebrospinal fluid
Immunoglobulin M cerebrospinal fluid
Meningitis, Aseptic immunology
Oligoclonal Bands
Polyradiculoneuropathy immunology
Immunoglobulin Light Chains cerebrospinal fluid
Immunoglobulin kappa-Chains cerebrospinal fluid
Immunoglobulin lambda-Chains cerebrospinal fluid
Immunoglobulins cerebrospinal fluid
Multiple Sclerosis immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0912-2036
- Volume :
- 42
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Japanese journal of psychiatry and neurology
- Publication Type :
- Academic Journal
- Accession number :
- 3150478
- Full Text :
- https://doi.org/10.1111/j.1440-1819.1988.tb01169.x