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Keep the cat, change the care pathway: A transformational approach to managing Fel d 1, the major cat allergen.
- Source :
-
Allergy [Allergy] 2019 Oct; Vol. 74 Suppl 107, pp. 5-17. - Publication Year :
- 2019
-
Abstract
- Background: Allergies to cats are the most common animal-origin allergy, and affect approximately 1 in 5 adults worldwide. The prevalence of allergy to furry animals has been increasing, and allergy to cats is a major risk factor for the development of asthma and rhinitis. The diagnosis of cat allergy is now well established. The exact significance of component-resolved diagnosis in the diagnosis of cat allergy remains to be fully understood. Allergen avoidance is effective but often has a psychologic impact. Allergen immunotherapy is not well demonstrated. There is a need for innovative approaches to better manage cat allergens. Next-generation care pathways for asthma and rhinitis will define the place of cat allergen avoidance.<br />Methods and Results: This manuscript, based on content presented at the European Academy of Allergy and Clinical Immunology Congress 2019, provides information on the prevalence and impact of cat allergies and the molecular biology of Fel d 1, the major cat allergen.<br />Discussion: The authors present the scientific basis of a novel care pathway that utilizes anti-Fel d 1 IgY antibodies to safely and effectively neutralize Fel d 1 after its production by the cat but before human exposure.<br />Conclusion: Efficacy of a feline diet with an egg product ingredient containing anti-Fel d 1 IgY antibodies was demonstrated in vitro, ex vivo, and in vivo, and further validated by a pilot exposure study involving cat-allergic human participants.<br /> (© 2019 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.)
- Subjects :
- Animals
Antibodies, Neutralizing adverse effects
Antibodies, Neutralizing immunology
Antibodies, Neutralizing metabolism
Cats
Chick Embryo
Desensitization, Immunologic
Diet methods
Epitopes immunology
Epitopes metabolism
Glycoproteins metabolism
Humans
Immunoglobulin E immunology
Immunoglobulins adverse effects
Immunoglobulins immunology
Immunoglobulins metabolism
Protein Binding
Saliva immunology
Allergens immunology
Asthma immunology
Asthma therapy
Glycoproteins immunology
Pets immunology
Rhinitis, Allergic immunology
Rhinitis, Allergic therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1398-9995
- Volume :
- 74 Suppl 107
- Database :
- MEDLINE
- Journal :
- Allergy
- Publication Type :
- Academic Journal
- Accession number :
- 31498459
- Full Text :
- https://doi.org/10.1111/all.14013