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Soft drugs for dermatological applications: recent trends.
- Source :
-
Drug discovery today [Drug Discov Today] 2019 Dec; Vol. 24 (12), pp. 2234-2246. Date of Electronic Publication: 2019 Sep 05. - Publication Year :
- 2019
-
Abstract
- A soft drug (SD) displays a metabolically labile spot and, after having exerted its activity in the site of action, undergoes a fast metabolism, leading to inactive metabolites. The SD approach has recently found widespread application in the dermatological field because it provides a means of localising the therapeutic effect in skin, while minimising systemic exposure. The literature is rapidly growing of successful examples of compounds targeting sphingosine-1-phosphate receptor 1 (S1PR1), transient receptor potential vanilloid 1 (TRPV1), Janus kinase (JAK), caspase 1, and histone deacetylase (HDAC), for the treatment of skin inflammatory, autoimmune, and oncological diseases. As a demonstration of the potential of this strategy, the SD approach recently led to the approval of crisaborole, a soft phosphodiesterase 4 (PDE4) inhibitor, for atopic dermatitis, while other agents are in clinical development.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Boron Compounds administration & dosage
Boron Compounds metabolism
Boron Compounds pharmacology
Bridged Bicyclo Compounds, Heterocyclic administration & dosage
Bridged Bicyclo Compounds, Heterocyclic metabolism
Bridged Bicyclo Compounds, Heterocyclic pharmacology
Dermatitis, Atopic drug therapy
Dermatologic Agents metabolism
Dermatologic Agents pharmacology
Humans
Phosphodiesterase 4 Inhibitors administration & dosage
Phosphodiesterase 4 Inhibitors metabolism
Phosphodiesterase 4 Inhibitors pharmacology
Dermatologic Agents administration & dosage
Drug Development
Skin Diseases drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1878-5832
- Volume :
- 24
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Drug discovery today
- Publication Type :
- Academic Journal
- Accession number :
- 31494188
- Full Text :
- https://doi.org/10.1016/j.drudis.2019.08.007