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Comparison of short- and long-term outcomes between anatomical subtypes of resected biliary tract cancer in a Western high-volume center.
- Source :
-
HPB : the official journal of the International Hepato Pancreato Biliary Association [HPB (Oxford)] 2020 Mar; Vol. 22 (3), pp. 405-414. Date of Electronic Publication: 2019 Sep 04. - Publication Year :
- 2020
-
Abstract
- Background: Outcomes for the four anatomical subtypes of biliary tract carcinoma (BTC) - intrahepatic, perihilar and distal cholangiocarcinoma (ICC, PHCC, DCC) and gallbladder carcinoma (GBC) - are often combined. However, large cohorts comparing short- and long-term outcomes for the anatomical subtypes of BTC are lacking.<br />Methods: All patients who underwent resection for pathology proven ICC, PHCC, DCC or GBC (2000-2016) from a single Western high-volume center were retrospectively selected. Clinicopathological characteristics, short- and long-term outcomes were compared between the four anatomical subtypes.<br />Results: Overall, 361 patients with resected BTC were included (33 ICC, 135 PHCC, 148 DCC, 45 GBC). Clavien-Dindo grade III or higher complications were 48%, 51%, 36% and 8% (p < 0.001) and 90-day mortality was 9%, 15%, 3%, 4% (p < 0.001), for ICC, PHCC, DCC, GBC. Median overall survival was 37, 42, 29 and 41 months (p = 0.722), for ICC, PHCC, DCC, GBC. Five-year survival ranged between 29% and 37%. Anatomical subtype was not an independent predictor for overall survival.<br />Conclusion: In this large single-center cohort of resected BTC, major morbidity and 90-day mortality varied between the four anatomical subtypes of BTC, mainly due to differences in surgical approach However, a significant difference in overall survival was not detected.<br /> (Copyright © 2019 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Aged
Bile Duct Neoplasms mortality
Bile Ducts, Intrahepatic
Cholangiocarcinoma mortality
Female
Gallbladder Neoplasms mortality
Hospitals, High-Volume
Humans
Male
Middle Aged
Postoperative Complications epidemiology
Retrospective Studies
Survival Rate
Time Factors
Treatment Outcome
Bile Duct Neoplasms pathology
Bile Duct Neoplasms surgery
Cholangiocarcinoma pathology
Cholangiocarcinoma surgery
Gallbladder Neoplasms pathology
Gallbladder Neoplasms surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1477-2574
- Volume :
- 22
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- HPB : the official journal of the International Hepato Pancreato Biliary Association
- Publication Type :
- Academic Journal
- Accession number :
- 31494056
- Full Text :
- https://doi.org/10.1016/j.hpb.2019.07.011