Possible Binding of Piperine in Mycobacterium tuberculosis RNA Polymerase and Rifampin Synergism.

Authors :: Murase LS
Perez de Souza JV
Meneguello JE
Seixas FAV
Hegeto LA
Scodro RBL
Siqueira VLD
Caleffi Ferracioli KR
Cardoso RF
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2019 Oct 22; Vol. 63 (11). Date of Electronic Publication: 2019 Oct 22 (Print Publication: 2019).
Publication Year :: 2019
Abstract: The activity of rifampin (RIF) and piperine was evaluated at the relative transcript levels of 12 efflux pumps (EPs), and an additional mechanism was proposed to be behind the synergic interactions of piperine plus RIF in Mycobacterium tuberculosis AutoDock v4.2.3 and Molegro v6 programs were used to evaluate PIP binding in M. tuberculosis RNA polymerase (RNAP). A hypothesis has been raised that piperine interferes in M. tuberculosis growth through RNAP inhibition, differently from what was previously endorsed for EP inhibition only.<br /> (Copyright © 2019 American Society for Microbiology.)

Subjects :: Alkaloids administration & dosage
Alkaloids metabolism
Antineoplastic Agents administration & dosage
Antineoplastic Agents metabolism
Benzodioxoles administration & dosage
Benzodioxoles metabolism
Binding Sites
Drug Synergism
Drug Therapy, Combination
Molecular Docking Simulation
Mycobacterium tuberculosis enzymology
Mycobacterium tuberculosis metabolism
Piperidines administration & dosage
Piperidines metabolism
Polyunsaturated Alkamides administration & dosage
Polyunsaturated Alkamides metabolism
Reverse Transcriptase Polymerase Chain Reaction
Rifampin administration & dosage
Rifampin metabolism
Alkaloids pharmacology
Antineoplastic Agents pharmacology
Benzodioxoles pharmacology
DNA-Directed RNA Polymerases metabolism
Mycobacterium tuberculosis drug effects
Piperidines pharmacology
Polyunsaturated Alkamides pharmacology
Rifampin pharmacology

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