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Epicardial, paracardial, and perivascular fat quantity, gene expressions, and serum cytokines in patients with coronary artery disease and diabetes.
- Source :
-
Polish archives of internal medicine [Pol Arch Intern Med] 2019 Nov 29; Vol. 129 (11), pp. 738-746. Date of Electronic Publication: 2019 Sep 03. - Publication Year :
- 2019
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Abstract
- Introduction: Obesity and diabetes mellitus (DM) are common disorders that increase cardiovascular risk and lead to coronary artery disease (CAD).<br />Objectives: The aim of our study was to assess the link between epicardial fat (EF) volume and paracardial fat (PF) volume, relative expressions of several genes in epicardial, paracardial, and perivascular fat and corresponding serum cytokines in patients with CAD in relation to DM.<br />Patients and Methods: A total of 66 consecutive patients (33 with DM) with multivessel CAD were included. We obtained cardiac magnetic resonance, serum cytokines levels, and their relative mRNA expressions in EF, PF, and perivascular fat samples of the following: adrenomedullin (ADM), fibroblast growth factor 21 (FGF21), transforming growth factor β (TGFβ), phospholipid transfer protein (PLTP), receptor for advanced glycation endproducts (RAGE), thrombospondin 1 (THSB1), and uncoupling protein 1 (UCP1).<br />Results: There were no differences in the anthropometric parameters or fat depots, except for higher epicardial fat volume in patients with DM (mean [SD], 105.6 [38.5] ml vs 84 [29.2] ml; P = 0.02). Patients with DM exhibited a significantly increased RAGE expression in EF (median [Q1-Q3], 0.17 [0.06-1.48] AU vs 0.08 [0.02-0.24] AU, P = 0.03). Diabetes was also associated with increased expression of ADM in EF and PF and decreased expression of FGF21 compared with patients without DM.<br />Conclusions: Patients with multivessel CAD and DM revealed increased volume and more dysfunctional profile of gene expressions in EF and significantly decreased expression of cardioprotective FGF21.
- Subjects :
- Aged
Aged, 80 and over
Biomarkers blood
Comorbidity
Coronary Artery Disease blood
Coronary Artery Disease epidemiology
Diabetes Mellitus blood
Diabetes Mellitus epidemiology
Female
Gene Expression Regulation
Humans
Male
Middle Aged
Obesity blood
Adipose Tissue physiopathology
Coronary Artery Disease physiopathology
Cytokines blood
Diabetes Complications physiopathology
Diabetes Mellitus physiopathology
Obesity complications
Obesity physiopathology
Pericardium physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1897-9483
- Volume :
- 129
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Polish archives of internal medicine
- Publication Type :
- Academic Journal
- Accession number :
- 31479091
- Full Text :
- https://doi.org/10.20452/pamw.14961