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Use of the CDR® plus NACC FTLD in mild FTLD: Data from the ARTFL/LEFFTDS consortium.
- Source :
-
Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2020 Jan; Vol. 16 (1), pp. 79-90. Date of Electronic Publication: 2020 Jan 06. - Publication Year :
- 2020
-
Abstract
- Introduction: Behavior/Comportment/Personality (BEHAV) and Language (LANG) domains were added to the Clinical Dementia Rating (CDR®) for improving evaluation of patients with frontotemporal lobar degeneration (FTLD) (CDR® plus NACC FTLD).<br />Methods: We analyzed the CDR® plus NACC FTLD among participants from the baseline visit of the Advancing Research and Treatment for Frontotemporal Lobar Degeneration/Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects Consortium.<br />Results: The CDR® plus NACC FTLD was able to detect early symptoms in the mildly impaired participants who were rated as CDR® sum of boxes (CDR®-SB) = 0. The CDR®-SB was not sensitive, particularly in participants with mild nonfluent/agrammatic primary progressive aphasia. Participants with familial and sporadic behavioral variant FTD exhibited similar CDR® plus NACC FTLD profiles except that language impairment was more frequent in participants with mild sporadic behavioral variant FTD. Adding the BEHAV and/or LANG domains to the CDR®-SB significantly enhanced discriminatory power in differentiating among the FTLD spectrum disorders.<br />Discussion: The BEHAV and LANG domains enable the CDR® plus NACC FTLD to capture early symptomatology of FTLD.<br /> (© 2019 the Alzheimer's Association.)
- Subjects :
- Adult
Aged
Behavior physiology
Cross-Sectional Studies
Female
Frontotemporal Dementia genetics
Frontotemporal Lobar Degeneration genetics
Humans
Middle Aged
Personality physiology
Frontotemporal Dementia diagnosis
Frontotemporal Lobar Degeneration diagnosis
Language
Mental Status and Dementia Tests statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1552-5279
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Alzheimer's & dementia : the journal of the Alzheimer's Association
- Publication Type :
- Academic Journal
- Accession number :
- 31477517
- Full Text :
- https://doi.org/10.1016/j.jalz.2019.05.013