Significant Value of 11 C-Acetate and 18 F-Fluorodeoxyglucose PET/Computed Tomography on 90 Y Microsphere Radioembolization for Hepatocellular Carcinoma.

Authors :: Ho CL
Chen S
Cheung SK
Leung TWT
Source :: PET clinics [PET Clin] 2019 Oct; Vol. 14 (4), pp. 459-467. Date of Electronic Publication: 2019 Jul 31.
Publication Year :: 2019
Abstract: Pretreatment dual-tracer ( <superscript>18</superscript> F-fluorodeoxyglucose and <superscript>11</superscript> C-acetate) PET/computed tomography (CT) has potential to predict treatment response for <superscript>90</superscript> Y microsphere radioembolization (RE) in patients with inoperable hepatocellular carcinoma (HCC). Patients with <superscript>11</superscript> C-acetate-avid HCC have a better response to <superscript>90</superscript> Y microsphere RE, and possibly better survival. Pretreatment dual-tracer PET/CT has a significant theranostic value on <superscript>90</superscript> Y microsphere RE in determining target tumor dose for HCCs with different cellular differentiation, metabolic tumor volume, and functioning liver volume, and can be used to prescribe individual injected activity of <superscript>90</superscript> Y microspheres.<br /> (Copyright © 2019 Elsevier Inc. All rights reserved.)

Full Text Access

Tools