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Single-Molecule Nonresonant Wide-Field Surface-Enhanced Raman Scattering from Ferroelectrically Defined Au Nanoparticle Microarrays.
- Source :
-
ACS omega [ACS Omega] 2018 Mar 15; Vol. 3 (3), pp. 3165-3172. Date of Electronic Publication: 2018 Mar 15 (Print Publication: 2018). - Publication Year :
- 2018
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Abstract
- Single-molecule detection by surface-enhanced Raman scattering (SERS) is a powerful spectroscopic technique that is of interest for the sensor development field. An important aspect of optimizing the materials used in SERS-based sensors is the ability to have a high density of "hot spots" that enhance the SERS sensitivity to the single-molecule level. Photodeposition of gold (Au) nanoparticles through electric-field-directed self-assembly on a periodically proton-exchanged lithium niobate (PPELN) substrate provides conditions to form well-ordered microscale features consisting of closely packed Au nanoparticles. The resulting Au nanoparticle microstructure arrays (microarrays) are plasmon-active and support nonresonant single-molecule SERS at ultralow concentrations (<10 <superscript>-9</superscript> -10 <superscript>-13</superscript> M) with excitation power densities <1 × 10 <superscript>-3</superscript> W cm <superscript>-2</superscript> using wide-field imaging. The microarrays offer excellent SERS reproducibility, with an intensity variation of <7.5% across the substrate. As most biomarkers and molecules do not support resonance enhancement, this work demonstrates that PPELN is a suitable template for high-sensitivity, nonresonant sensing applications.<br />Competing Interests: The authors declare no competing financial interest.
Details
- Language :
- English
- ISSN :
- 2470-1343
- Volume :
- 3
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- ACS omega
- Publication Type :
- Academic Journal
- Accession number :
- 31458575
- Full Text :
- https://doi.org/10.1021/acsomega.7b01285