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The role of leptin and adiponectin as mediators in the relationship between adiposity and hand and knee osteoarthritis.
- Source :
-
Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2019 Dec; Vol. 27 (12), pp. 1761-1767. Date of Electronic Publication: 2019 Aug 23. - Publication Year :
- 2019
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Abstract
- Objectives: To investigate associations of leptin and adiponectin levels with knee and hand osteoarthritis, and explore whether these mediate the association between adiposity and osteoarthritis.<br />Methods: This is a cross-sectional analysis of baseline data from the population-based Netherlands Epidemiology of Obesity study. Adiposity was assessed with body mass index (BMI) and percentage total body fat (%TBF). Osteoarthritis, defined as hand or knee osteoarthritis, was determined using American College of Rheumatology criteria. Fasting serum adipokine levels were measured using immunoassays. Associations between adiposity and osteoarthritis were examined with logistic regression, adjusted for age, sex, ethnicity and education, and additionally for leptin and adiponectin as potential mediators.<br />Results: In 6408 participants (56% women, median age 56 years), prevalence of osteoarthritis was 22% (10% isolated knee and 8% isolated hand osteoarthritis). Leptin levels were positively associated with osteoarthritis, while adiponectin levels were not. Leptin partially mediated the association of adiposity with osteoarthritis (OR 1.40 (95%CI 1.30; 1.52) attenuated to 1.38 (1.24; 1.54) per 5 units BMI and OR 1.25 (1.17; 1.35) to 1.20 (1.10; 1.32) per 5 units %TBF, representing 4% and 17% mediation, respectively). Larger proportion mediation by leptin was found in knee (13%/27%) than in hand osteoarthritis (9%/18%). Sex-stratified analyses generally showed stronger associations between adiposity, leptin and osteoarthritis in women than in men.<br />Conclusions: Serum leptin levels were associated with osteoarthritis, and partially mediated the association between adiposity and osteoarthritis, while adiponectin levels were not associated with osteoarthritis. These findings provide evidence for systemic effects of adipose tissue in osteoarthritis.<br /> (Copyright © 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Adiposity
Aged
Female
Humans
Logistic Models
Male
Middle Aged
Netherlands epidemiology
Obesity epidemiology
Osteoarthritis epidemiology
Osteoarthritis metabolism
Osteoarthritis, Knee epidemiology
Adiponectin metabolism
Hand Joints
Leptin metabolism
Obesity metabolism
Osteoarthritis, Knee metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1522-9653
- Volume :
- 27
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Osteoarthritis and cartilage
- Publication Type :
- Academic Journal
- Accession number :
- 31450004
- Full Text :
- https://doi.org/10.1016/j.joca.2019.08.003