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[Live Vaccine in Children with DiGeorge/22q11.2 Deletion Syndrome].
- Source :
-
Acta medica portuguesa [Acta Med Port] 2019 Aug 01; Vol. 32 (7-8), pp. 514-519. Date of Electronic Publication: 2019 Aug 01. - Publication Year :
- 2019
-
Abstract
- Introduction: Children with DiGeorge syndrome/chromosome 22q11.2 deletion syndrome might have a variable degree of immunodeficiency, which may limit the use of live vaccines. The aim of this study was to review the adverse effects of live vaccines and possible relation with immune status in patients with DiGeorge Syndrome/partial 22q11.2 deletion syndrome.<br />Material and Methods: Retrospective study with analysis of the clinical records of children with chromosome 22q11.2 deletion syndrome and DiGeorge syndrome phenotype, followed in a Primary Immunodeficiency center. Data were collected on: demographic characteristics; medical and vaccination history with live vaccines; T-CD4+ lymphocyte counts and lymphocyte proliferative responses to antigens and mitogens; adverse reactions; vaccine failure.<br />Results: Twenty three children with DiGeorge syndrome/22q11.2 deletion syndrome were included, 65.2% male, with average age at diagnosis of 11.3 months. Eighteen children (78%) received bacillus Calmette-Guérin vaccine: all with evidence of thymic activity; three presented moderate T-CD4+ lymphopenia and abnormal lymphocyte proliferative responses; one had abnormal lymphocyte proliferative responses for mitogens, four for purified protein derivative and one for tetanus toxoid. Measles, mumps and rubella vaccine was administered to 15 children, three of them with moderate immunosuppression and abnormal lymphocyte proliferative responses. Live attenuated polio vaccine was administered to 4 children without immunosuppression and the rotavirus vaccine to three children, one with moderate immunosuppression. No significant adverse reactions were reported.<br />Discussion: These data are in line with the findings of other international studies.<br />Conclusion: In our sample, live vaccines were well-tolerated, even in children with moderate T-CD4+ lymphopenia and abnormal lymphocyte proliferative responses to antigens/mitogens.
- Subjects :
- Adjuvants, Immunologic administration & dosage
BCG Vaccine administration & dosage
BCG Vaccine immunology
CD4-Positive T-Lymphocytes
Cell Proliferation
Child
Child, Preschool
Female
Humans
Immunocompromised Host
Infant
Lymphopenia immunology
Male
Measles-Mumps-Rubella Vaccine administration & dosage
Measles-Mumps-Rubella Vaccine immunology
Phenotype
Poliovirus Vaccine, Inactivated administration & dosage
Retrospective Studies
Rotavirus Vaccines administration & dosage
Vaccines, Attenuated administration & dosage
Vaccines, Attenuated immunology
DiGeorge Syndrome immunology
Immune Tolerance
Subjects
Details
- Language :
- Portuguese
- ISSN :
- 1646-0758
- Volume :
- 32
- Issue :
- 7-8
- Database :
- MEDLINE
- Journal :
- Acta medica portuguesa
- Publication Type :
- Academic Journal
- Accession number :
- 31445531
- Full Text :
- https://doi.org/10.20344/amp.9802