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Marine Natural Products: A Source of Novel Anticancer Drugs.

Authors :
Khalifa SAM
Elias N
Farag MA
Chen L
Saeed A
Hegazy MF
Moustafa MS
Abd El-Wahed A
Al-Mousawi SM
Musharraf SG
Chang FR
Iwasaki A
Suenaga K
Alajlani M
Göransson U
El-Seedi HR
Source :
Marine drugs [Mar Drugs] 2019 Aug 23; Vol. 17 (9). Date of Electronic Publication: 2019 Aug 23.
Publication Year :
2019

Abstract

Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.

Details

Language :
English
ISSN :
1660-3397
Volume :
17
Issue :
9
Database :
MEDLINE
Journal :
Marine drugs
Publication Type :
Academic Journal
Accession number :
31443597
Full Text :
https://doi.org/10.3390/md17090491