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Rise and rise of the ABC transporter families.
- Source :
-
Research in microbiology [Res Microbiol] 2019 Nov - Dec; Vol. 170 (8), pp. 304-320. Date of Electronic Publication: 2019 Aug 20. - Publication Year :
- 2019
-
Abstract
- This review will inevitably be influenced by my personal experience and personal view of the progression of this amazing family of proteins. This has generated a huge literature in over nearly five decades, some ideas have bloomed and faded while others have persisted, other contributions simply become redundant, overtaken by better techniques. At the outset, the pioneers had no idea of the magnitude of the topic they were working on, then a very rough idea of the significance emerged and, progressively, the picture becomes sharper and finally extraordinary. I have tried to produce at least an outline of that progression. My apologies for the also inevitable omissions, especially relating to the mass of biochemical and spectroscopy and genetical studies. I decided to prioritise structural biology because structures when successful are definitive and of course provide a 'visual' image. However, I tried to limit the structural aspects to the proteins that reflected the main advances.<br /> (Copyright © 2019. Published by Elsevier Masson SAS.)
- Subjects :
- ATP-Binding Cassette Transporters genetics
Biological Transport physiology
Drug Resistance, Bacterial genetics
Drug Resistance, Bacterial physiology
Lipid Metabolism physiology
Protein Conformation
ATP-Binding Cassette Transporters metabolism
Adenosine Triphosphate metabolism
Anti-Bacterial Agents metabolism
Bacteria metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1769-7123
- Volume :
- 170
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Research in microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 31442613
- Full Text :
- https://doi.org/10.1016/j.resmic.2019.08.004