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Effect of Pneumococcal Conjugate Vaccines on Pneumococcal Meningitis, England and Wales, July 1, 2000-June 30, 2016.
- Source :
-
Emerging infectious diseases [Emerg Infect Dis] 2019 Sep; Vol. 25 (9), pp. 1708-1718. - Publication Year :
- 2019
-
Abstract
- We describe the effects of the 7-valent (PCV7) and 13-valent (PCV13) pneumococcal conjugate vaccines on pneumococcal meningitis in England and Wales during July 1, 2000-June 30, 2016. Overall, 84,473 laboratory-confirmed invasive pneumococcal disease cases, including 4,160 (4.9%) cases with meningitis, occurred. PCV7 implementation in 2006 did not lower overall pneumococcal meningitis incidence because of replacement with non-PCV7-type meningitis incidence. Replacement with PCV13 in 2010, however, led to a 48% reduction in pneumococcal meningitis incidence by 2015-16. The overall case-fatality rate was 17.5%: 10.7% among patients <5 years of age, 17.3% among patients 5-64 years of age, and 31.9% among patients >65 years of age. Serotype 8 was associated with increased odds of death (adjusted odds ratio 2.9, 95% CI 1.8-4.7). In England and Wales, an effect on pneumococcal meningitis was observed only after PCV13 implementation. Further studies are needed to assess pneumococcal meningitis caused by the replacing serotypes.
- Subjects :
- Adolescent
Adult
Aged
Child
Child, Preschool
England epidemiology
Female
Heptavalent Pneumococcal Conjugate Vaccine administration & dosage
Humans
Incidence
Infant
Infant, Newborn
Male
Mass Vaccination
Meningitis, Pneumococcal mortality
Meningitis, Pneumococcal prevention & control
Middle Aged
Vaccines, Conjugate
Wales epidemiology
Young Adult
Meningitis, Pneumococcal epidemiology
Pneumococcal Vaccines administration & dosage
Streptococcus pneumoniae immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1080-6059
- Volume :
- 25
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Emerging infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 31441745
- Full Text :
- https://doi.org/10.3201/eid2509.180747