Comparison of Soybean-based Oil and MCT-olive-fish-soy Oil Intravenous Lipid Emulsions on Soluble Adhesion Markers in Preterm Neonates with Sepsis: A Randomized Controlled Trial.

Authors :: Abdelkareem M
Wahba Y
Shouman B
Mesbah A
Source :: Indian pediatrics [Indian Pediatr] 2019 Oct 15; Vol. 56 (10), pp. 841-844. Date of Electronic Publication: 2019 Aug 10.
Publication Year :: 2019
Abstract: Objective: To compare the effects of two different intravenous lipid emulsions on soluble adhesion markers in preterm infants with sepsis.<br />Methods: This randomized controlled pilot trial was conducted from February 2016 to February 2017. 40 preterm infants with sepsis were enrolled and assigned to receive either Medium chain triglyceride-Olive-Fish-Soy lipid emulsion (MOFS-LE) or soybean oil-based lipid emulsion (S-LE). Outcomes of the study were changes in sICAM-1 and leukocyte integrin b2 levels, and growth after 7 days of intervention.<br />Results: Leukocyte integrin b2 was significantly higher in MOFS-LE group. No statistically significant differences were observed for sICAM-1, duration of mechanical ventilation and antibiotics treatment, and mortality rate.<br />Conclusions: Leukocyte integrin b2 was significantly higher in preterm septic neonates who received MOFS-LE.

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