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Interference of Seasonal Variation on the Antimicrobial and Cytotoxic Activities of the Essential Oils from the Leaves of Iryanthera polyneura in the Amazon Rain Forest.
- Source :
-
Chemistry & biodiversity [Chem Biodivers] 2019 Oct; Vol. 16 (10), pp. e1900374. Date of Electronic Publication: 2019 Sep 11. - Publication Year :
- 2019
-
Abstract
- The essential oils (EOs) obtained from the leaves of Iryanthera polyneura Ducke trees was chemically Assessed and tested for the ability of inhibiting the growth of Candida albicans, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus mutans and S. sanguinis. The oil was also tested against breast (MCF-7) and prostate (PC-3) cancer cell lines. Minimum bactericidal concentrations (MBCs) and 50 % inhibition concentrations (IC <subscript>50</subscript> ) values were obtained. EOs were active against Gram-positive bacteria. Spathulenol, α-cadinol and τ-muurolol were major components of EOs. The oils showed a higher cytotoxicity against PC-3 than MCF-7 cells, although the oils were active against both cell types. Oils obtained from leaves collected in the dry season were more active against E. faecalis, S. aureus and PC-3, while the oils obtained from leaves collected in the rainy season were more active against S. mutans, S. sanguinis and MCF-7. The antibacterial and cytotoxic activities of the essential oils from the leaves of I. polyneura are related to the seasonal climate variation and are influenced by compounds that are minor components of the oils.<br /> (© 2019 Wiley-VHCA AG, Zurich, Switzerland.)
- Subjects :
- Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents chemistry
Antineoplastic Agents, Phytogenic chemical synthesis
Antineoplastic Agents, Phytogenic chemistry
Brazil
Cell Proliferation drug effects
Drug Screening Assays, Antitumor
Humans
MCF-7 Cells
Microbial Sensitivity Tests
Oils, Volatile chemical synthesis
Oils, Volatile chemistry
PC-3 Cells
Rainforest
Anti-Bacterial Agents pharmacology
Antineoplastic Agents, Phytogenic pharmacology
Myristicaceae chemistry
Oils, Volatile pharmacology
Plant Leaves chemistry
Seasons
Subjects
Details
- Language :
- English
- ISSN :
- 1612-1880
- Volume :
- 16
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Chemistry & biodiversity
- Publication Type :
- Academic Journal
- Accession number :
- 31441194
- Full Text :
- https://doi.org/10.1002/cbdv.201900374