Back to Search
Start Over
Red blood cell distribution width is an independent predictor of mortality for an acute exacerbation of COPD.
- Source :
-
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease [Int J Tuberc Lung Dis] 2019 Jul 01; Vol. 23 (7), pp. 817-823. - Publication Year :
- 2019
-
Abstract
- BACKGROUND: The prognostic role of the red blood cell distribution width (RDW) on an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is incompletely understood. OBJECTIVE: To investigate the effect of the RDW on in-hospital and 1-year mortality after an AECOPD. DESIGN: For 442 AECOPD patients, the RDW was measured and clinical characteristics, comorbidities and laboratory measurements were recorded. The RDW that discriminated survivors and non-survivors was determined using a receiver operator characteristic (ROC) curve. The risk factors for in-hospital and 1-year mortality were identified through logistic regression analysis and Cox regression analysis, respectively. RESULTS: Of 442 study patients, 31 died, and 411 survived while in hospital. The area under the ROC curve for RDW for in-hospital death was 0.726 (95%CI 0.631-0.822), with sensitivity of 0.71 and specificity of 0.64 for a cut-off point of 13.75%. An RDW ≥13.75% was a risk factor for in-hospital mortality (relative risk 4.30, 95%CI 1.98-9.58; P < 0.001). Univariate and multivariate Cox regression analysis showed that an RDW ≥13.75% was an independent risk factor for death at 1 year (univariate analysis, hazard ration [HR] 2.33, 95%CI 1.55-3.51; multivariate analysis, HR 1.64, 95%CI 1.08-2.50). CONCLUSION: The RDW was a strong and independent risk factor for in-hospital and 1-year death for AECOPD patients.
- Subjects :
- Aged
Aged, 80 and over
China
Female
Hospital Mortality
Humans
Male
Middle Aged
Predictive Value of Tests
Prognosis
Prospective Studies
Pulmonary Disease, Chronic Obstructive blood
ROC Curve
Risk Factors
Severity of Illness Index
Survival Analysis
Erythrocyte Indices
Pulmonary Disease, Chronic Obstructive mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1815-7920
- Volume :
- 23
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
- Publication Type :
- Academic Journal
- Accession number :
- 31439113
- Full Text :
- https://doi.org/10.5588/ijtld.18.0429