Wound healing potential of curcumin cross-linked chitosan/polyvinyl alcohol.

Authors :: Abbas M
Hussain T
Arshad M
Ansari AR
Irshad A
Nisar J
Hussain F
Masood N
Nazir A
Iqbal M
Source :: International journal of biological macromolecules [Int J Biol Macromol] 2019 Nov 01; Vol. 140, pp. 871-876. Date of Electronic Publication: 2019 Aug 19.
Publication Year :: 2019
Abstract: This study focusses on antibacterial properties and wound healing potential of curcumin cross-linked with chitosan-PVA membranes. The crude curcumin was extracted from the rhizome of (Curcumin longa) and chitosan-PVA 80 was also prepared separately. The synergistic potential 10, 20 and 30 mg of curcumin alone and in combination with chitosan-PVA was determined. The antibacterial, scavenging potential of free radical, total phenolic and total flavonoids contents were documented through spectrophotometric methods. Finally, the wound healing potential was tested on experimental animal (rabbits). Rabbits were divided into different groups; untreated (control), treated with 10, 20 and 30 mg of curcumin and its combination with chitosan-PVA80. Chitosan-PVA exhibited significant antibacterial property against bacterial pathogens. Wound healing trials on 2nd degree burns showed chitosan as substantial wound healing agent for wound bandages. Results have shown that chitosan wound gauzes augmented the granule and fibrous connective tissues formation.<br /> (Copyright © 2019 Elsevier B.V. All rights reserved.)