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Dosimetry verification of 3D-printed individual template based on CT-MRI fusion for radioactive 125 I seed implantation in recurrent high-grade gliomas.

Dosimetry verification of 3D-printed individual template based on CT-MRI fusion for radioactive 125 I seed implantation in recurrent high-grade gliomas.

Authors :
Liu S
Wang H
Wang C
Zhang H
Li W
Dong Q
Hu X
Source :
Journal of contemporary brachytherapy [J Contemp Brachytherapy] 2019 Jun; Vol. 11 (3), pp. 235-242. Date of Electronic Publication: 2019 Jun 28.
Publication Year :
2019

Abstract

Purpose: To verify the accuracy and efficacy of three-dimensional printing individual template (3D-PIT) with computed tomography-magnetic resonance imaging (CT-MRI) fusion for radioactive iodine-125 ( <superscript>125</superscript> I) seed implantation in high-grade brain gliomas.<br />Material and Methods: Between June 2017 and June 2018, 16 patients with recurrent high-grade gliomas (rHGG) underwent radioactive seed implantation with 3D-PIT. The prescribed dose was 120-140 Gy. We compared the dose distribution of the postoperative plan with the preoperative plan. Dose parameters included D <subscript>90</subscript> , V <subscript>100</subscript> , V <subscript>200</subscript> , conformity index (CI), and external index of the target volume (EI). Local control and early complications were also analyzed.<br />Results: Sixteen treatment areas were reported in our study. Median gross tumor volume (preoperative) of patients was 64.2 cm <superscript>3</superscript> , median needle number was 8, and median number of implanted <superscript>125</superscript> I seeds was 60. For postoperative plans, the median D <subscript>90</subscript> , V <subscript>100</subscript> , and V <subscript>200</subscript> was 152.1 Gy, 96.8%, and 49.1%, respectively, and 151.7 Gy, 97.0%, and 48.9%, respectively, in preoperative plans. Comparing with the preplanned cases, the dose of the target volume was slightly higher; the high-dose area of the target volume was larger in postoperative cases, but the difference was not statistically significant ( p > 0.05). Actual dose conformity of the target volume was greater than preplanned, and the difference was not statistically significant ( p > 0.05). Local control was 81.25% and 75% at 3 and 6 months after implantation, respectively. No serious early toxicities were observed.<br />Conclusions: 3D-PIT based on the CT-MRI fusion images can result in good accuracy for positioning and dose distribution in radioactive seed implantation for treatment of rHGG.<br />Competing Interests: Authors report no conflict of interest.

Details

Language :
English
ISSN :
1689-832X
Volume :
11
Issue :
3
Database :
MEDLINE
Journal :
Journal of contemporary brachytherapy
Publication Type :
Academic Journal
Accession number :
31435430
Full Text :
https://doi.org/10.5114/jcb.2019.85729