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Infectious uveitis in immunodeficient HIV-negative patients: A retrospective study.
- Source :
-
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia [Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub] 2020 Dec; Vol. 164 (4), pp. 410-416. Date of Electronic Publication: 2019 Aug 21. - Publication Year :
- 2020
-
Abstract
- Aims: Cases of infectious uveitis in immunodeficient patients may present with atypical clinical features because the clinical course of disease is usually affected by the compromised immune system. Therefore, it is sometimes difficult to determine the correct diagnosis. The aim of this study was to evaluate a prevalence of immunodeficient HIV-negative individuals among patients with infectious uveitis and to assess diagnostic and therapeutic approaches.<br />Methods: A retrospective study.<br />Results: In years 2003-2017, we diagnosed 594 patients with infectious uveitis. In 35 of them, infectious uveitis occurred on the basis of immunodeficiency (malignancy, immunosuppressive therapy etc.). The most common infectious uveitis was cytomegalovirus retinitis, followed by acute retinal necrosis, herpetic anterior uveitis, endogenous fungal endophthalmitis, toxoplasmic retinochoroiditis, progressive outer retinal necrosis and syphilis. In indicated cases, intraocular fluid examination was a valuable diagnostic tool. After initiation of treatment, improvement of BCVA was observed in 13 eyes, stabilization in 13 eyes and deterioration in 11 eyes. In some patients who experienced adverse effects of medication, the recommended doses were decreased.<br />Conclusion: Our experience shows that patients with diagnoses of acute retinal necrosis or progressive outer retinal necrosis have a poor visual prognosis. The occurrence of cytomegalovirus retinitis signifies a very unfavorable survival prognosis in patients who underwent hematopoietic stem cell transplantation; the patients in our study died within 1 year from cytomegalovirus retinitis diagnosis.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Czech Republic
Eye Infections, Viral physiopathology
Female
Humans
Male
Middle Aged
Retrospective Studies
Uveitis physiopathology
Young Adult
Eye Infections, Viral diagnosis
Eye Infections, Viral etiology
Eye Infections, Viral therapy
Immunocompromised Host
Uveitis diagnosis
Uveitis etiology
Uveitis therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1804-7521
- Volume :
- 164
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
- Publication Type :
- Academic Journal
- Accession number :
- 31435074
- Full Text :
- https://doi.org/10.5507/bp.2019.036