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A new dineolignan with anti- β -amyloid aggregation activity from the fruits of crataegus pinnatifida bge.
- Source :
-
Natural product research [Nat Prod Res] 2021 Jun; Vol. 35 (12), pp. 2112-2115. Date of Electronic Publication: 2019 Aug 20. - Publication Year :
- 2021
-
Abstract
- A new dineolignan, crataeguslignan A ( 1 ), along with one known dineolignan ( 2) were isolated from the fruits of Crataegus pinnatifida Bge. Its chemical structure was identified by comprehensive spectroscopic analyses. All the isolated compounds were investigated with regard to their A β <subscript>1-42</subscript> inhibition activity. Among them, 1 displayed the most potent A β <subscript>1-42</subscript> inhibitory ability with the inhibition rate of 85.2% at the concentration of 20 μM.
- Subjects :
- Amyloid beta-Peptides metabolism
Fruit chemistry
Molecular Structure
Peptide Fragments metabolism
Plants, Medicinal chemistry
Protein Aggregates drug effects
Spectrometry, Mass, Electrospray Ionization
Amyloid beta-Peptides antagonists & inhibitors
Crataegus chemistry
Lignans chemistry
Peptide Fragments antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6427
- Volume :
- 35
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Natural product research
- Publication Type :
- Academic Journal
- Accession number :
- 31429298
- Full Text :
- https://doi.org/10.1080/14786419.2019.1655415