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A young woman with seizures, visual impairment, and paralysis.
- Source :
-
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke [Tidsskr Nor Laegeforen] 2019 Aug 19; Vol. 139 (11). Date of Electronic Publication: 2019 Aug 19 (Print Publication: 2019). - Publication Year :
- 2019
-
Abstract
- Background: Anti-MOG encephalomyelitis is a recently described demyelinating, autoimmune disease of the central nervous system, identified by antibodies against myelin oligodendrocyte glycoprotein (MOG).<br />Case Presentation: A previously healthy 20-year-old woman was admitted to hospital after a seizure. MRI showed leptomeningeal enhancement and lumbar puncture revealed moderate pleocytosis but no evidence of infection. Over the following months, she experienced a series of neurological deficits including bladder dysfunction, loss of sensation in the lower extremities and genital area, impaired motor function of the legs and episodes of visual loss. All symptoms had MRI correlates in the medulla, brainstem, optic tract, thalami and corpus callosum. She responded excellently to corticosteroid treatment, but experienced relapses shortly after discontinuation of treatment. Repeated lumbar puncture revealed pleocytosis up to 475 ∙ 106 cells/l but there were no signs of intrathecal IgG synthesis or infection. Serum anti-MOG antibodies were detected two months after the initial episode. She has been treated with low dose corticosteroids in combination with rituximab for two years, without clinical or radiological relapse.<br />Interpretation: Symptoms and signs mimicking acute demyelinating encephalomyelitis and neuromyelitis optica are typical for anti-MOG encephalomyelitis. This case illustrates that the response to corticosteroids may be excellent but transient, and that the disease can be controlled with moderate immunosuppression.
- Subjects :
- Female
Humans
Magnetic Resonance Imaging
Paralysis etiology
Seizures etiology
Vision Disorders etiology
Young Adult
Encephalomyelitis cerebrospinal fluid
Encephalomyelitis complications
Encephalomyelitis diagnostic imaging
Encephalomyelitis immunology
Myelin-Oligodendrocyte Glycoprotein immunology
Subjects
Details
- Language :
- Norwegian; English
- ISSN :
- 0807-7096
- Volume :
- 139
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke
- Publication Type :
- Report
- Accession number :
- 31429234
- Full Text :
- https://doi.org/10.4045/tidsskr.19.0122