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Multifunctional prosthetic polyester-based hybrid mesh for repairing of abdominal wall hernias and defects.
- Source :
-
Carbohydrate polymers [Carbohydr Polym] 2019 Nov 01; Vol. 223, pp. 115027. Date of Electronic Publication: 2019 Jul 05. - Publication Year :
- 2019
-
Abstract
- This study involves the design, development and evaluation of a new multifunctional prosthetic mesh for treatment of abdominal wall defects without complications. The developed prosthetic mesh is a hybrid platform of both synthetic and natural materials with its backbone consisting of a synthetic commercial polyester fabric (CPF) to provide the required mechanical integrity. The CPF mesh was coated by a natural biodegradable, biocompatible and antimicrobial layer of chitosan (CS) incorporating phenytoin (PH)-loaded pluronic nanomicelles for healing promotion, and ciprofloxacin (CPX)-alginate polyelectrolyte complex-based microparticles as antibacterial agent. The prosthetic mesh was optimized and evaluated in-vitro and in-vivo. The optimum PH-loaded micelles had particle size of 95.42 nm, polydispersity index of 0.41, zeta potential of -18 and entrapment efficiency of 89.4%, while the optimum CPX microcomplexes had particle size of 1292.0 nm, polydispersity index of 0.8, zeta potential of -20.1, complexation efficiency of 81.1%, and minimum inhibitory concentration of 0.25 μg/ml and 0.125 μg/ml against Staphylococcus aureus and Pseudomonas aeruginosa, respectively. In-vivo study on abdominal wall defect dog model was conducted, followed by implantation of the proposed prosthetic meshes. The developed mesh depicted an efficient healing with excellent biocompatibility, and could be an ideal and feasible alternative prosthesis with many advantages such as low cost, inertness, mechanical stability, pliability, low infection rate, limited modification by body tissues, sterilizability, non-carcinogenicity, limited inflammatory reaction, hypoallergenic as well as minimal complications.<br /> (Copyright © 2019 Elsevier Ltd. All rights reserved.)
- Subjects :
- Abdominal Wall pathology
Alginates pharmacology
Animals
Anti-Bacterial Agents pharmacology
Ciprofloxacin pharmacology
Dogs
Drug Delivery Systems
Female
Hernia, Abdominal pathology
Male
Micelles
Phenytoin pharmacology
Wound Healing drug effects
Abdominal Wall surgery
Chitosan chemistry
Hernia, Abdominal surgery
Polyesters chemistry
Prostheses and Implants
Surgical Mesh
Subjects
Details
- Language :
- English
- ISSN :
- 1879-1344
- Volume :
- 223
- Database :
- MEDLINE
- Journal :
- Carbohydrate polymers
- Publication Type :
- Academic Journal
- Accession number :
- 31426976
- Full Text :
- https://doi.org/10.1016/j.carbpol.2019.115027