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Enteropathogen antibody dynamics and force of infection among children in low-resource settings.
- Source :
-
ELife [Elife] 2019 Aug 19; Vol. 8. Date of Electronic Publication: 2019 Aug 19. - Publication Year :
- 2019
-
Abstract
- Little is known about enteropathogen seroepidemiology among children in low-resource settings. We measured serological IgG responses to eight enteropathogens ( Giardia intestinalis, Cryptosporidium parvum, Entamoeba histolytica, Salmonella enterica , enterotoxigenic Escherichia coli , Vibrio cholerae, Campylobacter jejuni , norovirus) in cohorts from Haiti, Kenya, and Tanzania. We studied antibody dynamics and force of infection across pathogens and cohorts. Enteropathogens shared common seroepidemiologic features that enabled between-pathogen comparisons of transmission. Overall, exposure was intense: for most pathogens the window of primary infection was <3 years old; for highest transmission pathogens primary infection occurred within the first year. Longitudinal profiles demonstrated significant IgG boosting and waning above seropositivity cutoffs, underscoring the value of longitudinal designs to estimate force of infection. Seroprevalence and force of infection were rank-preserving across pathogens, illustrating the measures provide similar information about transmission heterogeneity. Our findings suggest antibody response can be used to measure population-level transmission of diverse enteropathogens in serologic surveillance.<br />Competing Interests: BA, DM, JJ, HM, JO, GC, RO, EG, JM, VC, JV, PL, JP No competing interests declared
- Subjects :
- Age Factors
Child
Developing Countries
Disease Transmission, Infectious
Epidemiological Monitoring
Haiti epidemiology
Humans
Kenya epidemiology
Longitudinal Studies
Seroepidemiologic Studies
Tanzania epidemiology
Antibodies, Bacterial blood
Antibodies, Protozoan blood
Antibodies, Viral blood
Bacterial Infections epidemiology
Caliciviridae Infections epidemiology
Immunoglobulin G blood
Intestinal Diseases, Parasitic epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 2050-084X
- Volume :
- 8
- Database :
- MEDLINE
- Journal :
- ELife
- Publication Type :
- Academic Journal
- Accession number :
- 31424386
- Full Text :
- https://doi.org/10.7554/eLife.45594